Irizarry E, Restivo A, Salama M, et al. - Researchers undertook this three armed, double-blind, comparative effectiveness study to compare ibuprofen, ketorolac, and diclofenac for the management of acute, non-radicular low back pain (LBP). Patients were enrolled at the conclusion of an ED visit for musculoskeletal LBP. For ascertaining outcomes, they were inquired via telephone 5 days later. Patients were randomly assigned to receive a 5 day supply of ibuprofen 600 mg, ketorolac 10 mg, or diclofenac 50 mg, each to be used TID PRN. Improvement in Roland Morris Disability Questionnaire (RMDQ) between ED visit and day 5, was set as the primary outcome. The observed improvements in RMDQ by day 5 were: ibuprofen 9.4, ketorolac 11.9, diclofenac 10.9. In terms of the primary outcome, no important differences were found between groups. These observations do not rule out the possibility that better pain relief and less stomach irritation are conferred by ketorolac compared with ibuprofen.