Hawk K, Grau LE, Fiellin DA, et al. - Researchers sought to report on the perspectives of patients regarding substance use therapy, perceived needs, and contextual factors that shape the choice of patients seen in the emergency department (ED) to engage with treatment and other patient support services in the acute post–opioid overdose period. Twenty four adult ED patients receiving care after an acute opioid overdose were administered a brief quantitative survey and included in semistructured interviews. Using constant comparison method and thematic analysis, researchers here identified eight themes as influencing participants’ consideration of OUD treatment and other services: (1) perceptions regarding control of drug use, (2) personal experience with substance use therapy, (3) role of interpersonal relationships, (4) provider communication skills, (5) stigma, (6) availability of ED resources, (7) impact of treatment policies, and (8) support for unmet basic needs. Overall, patients were identified as willing to discuss their opioid use and its treatment in the ED and report a number of unmet needs. ED‐based research was identified to have a role in evaluating a patient‐oriented approach to engage patients after opioid overdose.