Saleh MA - Herein, the author compared the early relapsing (before 12 months) and late relapsing pemphigus (after 24 months) patients, who were treated with rituximab (RTX) therapy. It was noted that following these cases closely for the initial 12 months following RTX therapy, was important as the patients with high baseline anti-Dsg1 indices relapsed earlier. A maintenance RTX dose during the first 12 months after RTX therapy could be required by these patients.