Sridhar J, et al. - In a prospective, randomized comparative study, experts evaluated the clinical outcomes of plain gut vs polyglactin 910 (PG910) sutures for sclerotomy closure after 23-gauge pars plana vitrectomy. They undertook a single-masked, randomized, prospective study with 49 eyes of 49 patients who underwent 23-gauge pars plana vitrectomy randomized to sclerotomy closure with either plain gut suture, PG910 (Vicryl) suture or a combination of the 2. Compared with the use of an 8-0 PG910 suture to close 23-gauge sclerotomies, plain gut suture led to improved tolerability and reduced inflammation. At the 1-month postoperative visit, greater pain was demonstrated by the patients with PG910 sutures than those with plain gut sutures.