Ahuja R, et al. – This study was designed not only to examine the changes in cytokine profile in the gingival crevicular fluid (GCF) secondary to heavy orthodontic forces but also to compare the cytokine expression between participants showing high and low root resorption. Findings revealed that interleukin 7 (IL-7) and tumour necrosis factor alpha {TNF-α} (pro–resorptive cytokine) increased significantly secondary to a high–level of orthodontic force application. Significantly high levels of granulocyte macrophage colony–stimulating factor (anti–resorptive cytokine) were identified in mild root resorption cases secondary to high–level orthodontic force application.