Heerspink HJL, Cherney D, Postmus D, et al. - Treatment with dapagliflozin in patients with chronic kidney disease (CKD) and substantial albuminuria was shown to confer a reduction in the risk of abrupt declines in kidney function.

• This is a pre-specified analysis of DAPA-CKD (Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease, a randomized, double-blind, placebo-controlled trial with a median follow-up of 2.4 years).

• Adults with CKD (urinary albumin-to-creatinine ratio 200–5000 mg/g and estimated glomerular filtration rate 25–75 mL/min/1.73m ² ) were randomly assigned to dapagliflozin 10 mg/day matched to placebo (2152 persons each).

• Serum creatinine doubling happened in 63 (2.9%) and 91 (4.2%) participants in the dapagliflozin and placebo groups, respectively (hazard ratio 0.68).

• No heterogeneity was evident in the impact of dapagliflozin on abrupt reductions in renal function based on baseline subgroups.

• In dapagliflozin and placebo groups, 52 (2.5%) and 69 (3.2%) participants suffered acute kidney injury-related serious adverse events, respectively (0.77).