This study reveals outcomes in 12 patients presenting with nail matrix psoriasis, limited to few nails, treated with intralesional injections of 25mg/ml methotrexate or 10mg/ml triamcinolone acetonide. Comparison was made between both options for response to therapy and follow-up results.

• Every 6 weeks for 24 weeks, patients received treatments and then observed for 6 months.

• During each session and at each follow up visit, a photographic documentation and a NAPSI scoring were obtained.

• At the end of the 4 sessions, disease improved in all cases and these data were corroborated at follow up particularly for the methotrexate treated group.