Zhou S, Gu L, Shi Z, et al. - A nomogram model containing three clinical parameters was constructed that could aid in predicting the recurrence risk of condyloma acuminatum (CA), a sexually transmitted disease caused by HPV, following 5-aminolevulinic acid photodynamic therapy (ALA-PDT).

• The training cohort comprised 346 CA patients treated with ALA-PDT and the validation cohort comprised 123 CA patients.

• In the training cohort, recurrences were reported in 55 (15.89%) patients after ALA-PDT.

• LASSO regression revealed the following as predictors of recurrence: concomitant HIV infection, skin and mucosa as affected area, and more than one time of CO₂ laser therapy.

• In the training cohort and the validation cohort, the C-indexes were 0.843 and 0.831 respectively indicating a good performance of the nomogram in predicting recurrence.

• The nomogram was identified as clinically useful in decision curve analysis when the intervention was determined at the non-adherence possibility threshold of 5%.