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A novel expression signature from the perspective of mesenchymal-epithelial transition for hepatocellular carcinoma with regard to prognosis, clinicopathological features, immune cell infiltration, chemotherapeutic efficacy, and immunosuppressive molecule

Journal of Oncology Aug 03, 2021

Xu L, et al. - Since mesenchymal-epithelial transition (MET), a reverse biological process to epithelial-mesenchymal transition, is involved in tumor metastasis and invasion, researchers conducted this investigation to analyze the role of MET-related genes (MRGs) in hepatocellular carcinoma (HCC) prognosis. MRGs data and clinical information were obtained from public databases. In the univariate Cox analysis, 37 MRGs were found to be linked with overall survival out of 148 differentially expressed MRGs. The authors created and validated a new signature from the standpoint of MET, which was found to be significantly associated with HCC prognosis, clinicopathological features, immune status, chemotherapeutic efficacy, and immunosuppressive biomarkers.

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