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A nomogram to predict survival of patients with intermediate-stage hepatocellular carcinoma after transarterial chemoembolization combined with microwave ablation

European Radiology Jan 10, 2020

Ni JY, Fang ZT, Sun HL, et al. - Based on the albumin–bilirubin (ALBI) grade, researchers created a prognostic nomogram for predicting the long-term survival of cases with intermediate-stage hepatocellular carcinoma (HCC) after transarterial chemoembolization combined with microwave ablation (TACE-MWA). Among 546 consecutive patients with intermediate-stage HCC who underwent TACE-MWA between January 2000 and December 2016, 380 patients had died after a median follow-up of 35.0 months (range, 4.0–221.0 months). On performing multivariate analyses, they identified overall mortality to be independently correlated with Eastern Cooperative Oncology Group performance status score more than 0, presence of liver cirrhosis, a-fetoprotein level above 400 ng/mL, tumor size greater than 5 cm, tumor number more than 3, advanced ALBI grade, and treatment sessions of TACE or MWA fewer than 3. Incorporation of these eight predictors in the prognostic nomogram led to the achievement of good calibration and discriminatory abilities with a concordance index of 0.770.
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