Schols AMR, et al. - In order to ensure acute coronary syndrome (ACS) could be safely ruled out in patients referred to secondary care for suspected ACS, researchers assessed the Marburg Heart Score (MHS), a clinical decision rule, or sought to create an adapted clinical decision rule for family physicians (FPs) in this 2-week, nationwide, prospective, observational, flash-mob study. They also investigated if it is feasible to use the flash-mob method, an innovative study design, for large-scale investigation in family medicine. They found that the use of MHS or FP clinical assessment failed to safely rule out ACS in patients referred to emergency care. Sensitivity of the MHS (cut-off ≤2) was 75.0%, specificity was 44.0%, positive predictive value was 24.3%, and negative predictive value was 88.0%. For the FP assessment (cut-off ≤5), these values were 86.7%, 41.4%, 25.2%, and 93.2%, respectively. For investigating relatively simple, clinically relevant research questions in family medicine on a large scale and over a relatively short duration, the possible feasibility of the flash-mob study design as an alternative investigation approach was suggested.