Pollock YYG, et al. - In this phase 2 study of men with prostate cancer, researchers tested the efficacy of a strategy that involved participation in a multidisciplinary clinic (MDC) designed to provide individualized lifestyle modification and management of androgen deprivation therapy (ADT)-related side effects. In a 1:1 ratio, randomization to either the MDC (n=25) or standard of care (SOC) (n=23) was carried out in patients who had started ADT < 6 months before enrollment, and in whom ADT was planned for at least 12 months following enrollment. From baseline to 12-month follow up in patients in the MDC arm vs SOC, a tendency towards more favorable mean percent change in systolic blood pressure (BP) (6.5% vs 10.3%), diastolic BP (-3.9% vs 10.0%), waist circumference (2.5% vs 4.0%), hemoglobin A1C (HbgA1C)(-2.4% vs -1.7%), insulin resistance (0.5% vs 1.9%), and fasting lipids (total cholesterol: 7.0% vs 21.8%; LDL: -2.9% vs 7.6%; triglyceride: 15.5% vs 37.2%) was observed. Based on these findings, a multidisciplinary approach was feasible and appeared to offer some benefit over SOC.