Blume-Peytavi U, Tosti A, Falqués M, et al. - Terbinafine 10% nail lacquer was examined for its safety and efficacy in distal-lateral subungual onychomycosis (DLSO).

• Researchers randomized patients with mild-to-moderate DLSO (3:3:1) to receive double-blind topical terbinafine 10% (n = 406) or its vehicle (n = 410) administered once daily for 4 weeks and then once weekly for 44 weeks, or open-label topical amorolfine 5% (n = 137) for 48 weeks, with a 12-week follow-up period.

• At Week 60, complete cure rates of 5.67%, 2.20% and 2.92% were recorded in the terbinafine, vehicle and amorolfine groups, respectively.

• Overall findings suggest that mild-to-moderate onychomycosis can be effectively treated using terbinafine 10% nail lacquer improving both clinical and mycological criteria compared with vehicle.

• When compared with the currently available topical agent, amorolfine 5%, terbinafine 10% nail lacquer may be some beneficial.

• Treatment was well-tolerated and safe.