Milési C, et al. - In young infants with acute viral bronchiolitis (AVB), researchers performed a multicenter randomized controlled trial of a 3-L/kg/min vs 2-L/kg/min high-flow nasal cannula (HFNC) flow rate. This trial was performed in 16 pediatric intensive care units (PICUs) to compare these two flow rates in infants up to 6 months old with moderate to severe AVB and treated with HFNC. They found comparable rates of intubation, and durations of invasive and noninvasive ventilation were also similar. In this analysis, no patient had air leak syndrome or died. According to the findings obtained, 3 L/kg/min did not reduce the risk of failure vs 2 L/kg/min in young infants with AVB supported with HFNC. The most common cause of failure was worsening respiratory distress.