Wang TS, et al. - Utilizing a larger, multi-institutional cohort, researchers sought to validate whether lateralization could be predicted, based on the ratio of aldosterone/cortisol levels (A/C) between the left adrenal vein (LAV) and inferior vena cava (IVC), with a 100% positive predictive value (PPV). Findings failed to validate the previously reported PPV of LAV/IVC ratio for lateralization. They recommended practicing caution in interpreting incomplete adrenal venous sampling (AVS) data to differentiate between unilateral or bilateral adrenal disease and giving strong consideration to repeat AVS prior to adrenalectomy.