Walton DM, et al. - Researchers investigated the influences of pretrauma life stress on posttrauma pain severity, and 2 potential mediating pathways, 1 biological (C-reactive protein, CRP) and 1 contextual (sleep quality). For this observational cross-sectional mediation analysis, they used data gathered from participants within 3 weeks of a noncatastrophic musculoskeletal trauma. Among the 112 participants, 54.6% were female, and 52.7% reported high pretrauma life stress. The high-stress and low-stress groups differed significantly in pain severity, sleep interference, and CRP. In mediation analysis, they identified pretrauma stress to be linked with pain severity only through its correlation with sleep interference, while CRP did not mediate the correlation.