Tabernero C, et al. - Given the association of several psychosocial factors associated with quality of life during cardiovascular disease (CVD), researchers examined the roles of conscientiousness, subjective wellbeing and self-efficacy beliefs. They assessed 514 patients (mean age 63.57 years) twice over a 9-month interval (Time 1 and Time 2) regarding conscientiousness, perceived subjective wellbeing (positive and negative affect, life satisfaction), cardiac self-efficacy and health-related quality of life (HRQoL). Results indicated a positive correlation of conscientiousness with subjective wellbeing, cardiac self-efficacy, and HRQoL at Time 1. Moreover, a positive longitudinal effect of cardiac self-efficacy at Time 1 on HRQoL at Time 2 was observed, while controlling for autoregressive effects. As per mediation analyses, positive affect and cardiac self-efficacy mediate the relationship between conscientiousness and HRQoL. Results thereby infer the utility of psychosocial interventions aimed at improving positive affect and self-efficacy beliefs among CVD patients.