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A large cohort study of body mass index and pancreatic cancer by smoking status

Cancer Epidemiology, Biomarkers & Prevention Oct 25, 2020

Jacobs EJ, Newton CC, Stevens VL, et al. - In adults who stated their smoking status at enrollment into Cancer Prevention Study-II in 1982, researchers assessed the link between BMI and pancreatic cancer mortality. Participants were never smokers (n = 420,543), former cigarette smokers (n= 282,244), and current cigarette smokers (n = 219,885). Death due to pancreatic cancer was noted in 7,904 participants during follow-up from 1985 to 2014. Compared to never-smokers, BMI was significantly less strongly linked with pancreatic cancer mortality among current smokers reporting ≥20 cigarettes/day. BMI was not associated with pancreatic cancer mortality among current smokers during follow-up within 10 years of enrollment, when current smokers at enrollment were the most likely to have still been smoking. According to the findings of this study, there was a weaker link between BMI and pancreatic cancer in current smokers vs in never smokers.

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