Lynch KT, Cramer CL, Kane WJ, et al. - Occurrence of Clostridioides difficile infection is reported after 2.2% of colorectal operations and its association has been observed with longer length of hospital stay, greater overall healthcare cost, and significant morbidity and mortality. Researchers here examined if and how prior Clostridioides difficile infection affects patients undergoing stoma reversal. It is hypothesized that cases with a history of Clostridioides difficile infection who underwent stoma reversal will be at an raised risk of postoperative Clostridioides difficile infection compared with patients without a history of Clostridioides difficile infection. In this observational cohort study of patients undergoing elective stoma reversal surgery by colorectal surgeons, they assessed a total of 445 patients. A history of Clostridioides difficile infection was reported in 42 of these patients before the stoma reversal. Findings revealed higher rates of postoperative Clostridioides difficile infection and greater risk of postoperative complications, discharge to a skilled facility, and 30-day readmission among patients with a prior history of Clostridioides difficile infection who underwent stoma reversal.