Alves-Ferreira M, Quintas M, Sequeiros J, et al. - Researchers performed this case-control study to examine the role and interaction of NRXN2, SYT1, GABRE, and CASK in migraine susceptibility. In total, 183 unrelated patients with migraine (148 females and 35 males) and 265 migraine-free controls (202 females and 63 males) were involved in the study, after excluding cases with familial hemiplegic migraine. For the first time, this study elucidates the gene-gene interactions between NRXN2, GABRE (a GABA _A-receptor), and CASK; more importantly, it demonstrates the synergistic effect of those genes and their relationship to migraine susceptibility. These gene interactions, which may be part of a larger network, have the potential to aid in the understanding of migraine aetiology and the development of new therapeutic approaches.