Ali MA, et al. - In this prospective randomized double-blind study, researchers investigated a dose of intrathecal fentanyl, which can improve the quality of surgical anesthesia with minimal side effects in parturients undergoing cesarean section under spinal anesthesia with intrathecal bupivacaine. Random allocation of 243 parturients undergoing cesarean section under spinal anesthesia to receive 10, 15, or 25 μg of intrathecal fentanyl with 10 mg of 0.5% hyperbaric bupivacaine, was carried out. Taking into account pain score, need for rescue analgesia, conversion to general anesthesia, and complaints of inadequacy of surgical anesthesia, these patients were assessed for clinical efficacy. Findings demonstrated that adequate surgical anesthesia and analgesia with minimal side effects was achieved by administering 10 or 15 μg of intrathecal fentanyl with 10 mg of bupivacaine in patients undergoing cesarean section.