Romeo V, Stanzione A, Gaudieri V, et al. - This study was carried out to evaluate the quality of guidelines on clinical indications for the use of ¹⁸F-FDG PET/CT in oncology using the AGREE II tool. The current literature was searched to identify guidelines focused on clinical indications for the use of ¹⁸F-FDG PET/CT in oncology between March and May 2019. Four independent appraisers assessed the quality of the selected guidelines using the AGREE II tool, which is organized in six quality domains accounting for a total of 23 items. It is demonstrated that a heterogeneous quality of guidelines dealing with clinical indications for the use of ¹⁸F-FDG PET/CT in oncology emerged from this analysis. Further study is needed to enhance the reporting of the applied methodology as well as to promote the applicability of guidelines into clinical practice.