Han GJ, et al. - Researchers analyzed literature dated from 1980 to 2020 defining the complication rates of liver transplantation patients undergoing either total hip or knee arthroplasty, via this systematic review and meta-analysis. For analysis purposes, four cohorts were defined: liver transplant patients receiving THA and TKA (1), THA only (2), TKA only (3), and controls (4). This meta-analysis involved 13 studies with 3,024 liver transplantation patients. Findings revealed that functional benefit was achieved with total hip and knee arthroplasty in liver transplantation patients, but this benefit was experienced at the cost of elevated risk of infection, revision/reoperation, and medically related complications relative to controls. Mortality may also represent a short-term risk.