Perry TA, et al. - Using contrast-enhanced (CE) magnetic resonance imaging (MRI), researchers assessed the impact of vitamin D therapy (800 IU cholecalciferol daily) on synovial tissue volume (STV) and subchondral bone marrow lesion (BML) volume in patients with symptomatic knee osteoarthritis (OA). They analyzed data from 50 participants (active, n=24; placebo, n=26) who partook in the randomized, placebo-controlled UK VIDEO trial, which investigated the influence of vitamin D therapy (800 IU cholecalciferol daily) on radiographic joint space narrowing. Overall, they observed no significant variation between the vitamin D and placebo groups in the mean change from baseline for STV and subchondral BML volume at 2 years follow-up.