Schwantes-An TH, et al. - In this investigation, researchers tested the premise that cardiovascular events and/or mortality are associated with polymorphisms in fibroblast growth factor 23 (FGF23), its co-receptor alpha-klotho (KL), and/or FGF23 receptors (FGFR). For this investigation, they analyzed 1,494 DNA samples collected at baseline from the Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events Trial. Study participants were randomized to either calcimimetic cinacalcet or placebo for the treatment of secondary hyperparathyroidism. In patients who received dialysis with moderate to severe secondary hyperparathyroidism, rs11063112 was related to HF and cardiovascular mortality. There were no statistically significant associations between FGF23 rs13312789 and single-nucleotide polymorphisms in FGFR4 or KL genes and the results of interest.