Yeh JJ, et al. - Researchers assessed how coronary artery disease (CAD) and stroke risks were impacted by statin use in asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) patients by evaluating retrospectively enrolled patients treated with (N = 916) and without (N = 6338) statins. They used time-dependent Cox proportional regression to determine the cumulative incidence of CAD and stroke (ischemic and hemorrhagic). In the statin users (long-term [>600 days] and short-term [≤600 days]) vs the nonusers, the adjusted hazard ratios (aHRs) and their 95% confidence intervals (CIs) for CAD or stroke were estimated following adjustment for sex, age, comorbidities, inhaled corticosteroid steroid (ICS) use, and oral steroid (OS) use. In all the statin users irrespective of use duration, a lower CAD risk was observed, while only the long-term statin users had lower ischemic stroke risk. Findings revealed statin use had no link to hemorrhagic stroke risk.