Patel KV, et al. - The National Health and Aging Trends Study, a nationally representative, prospective study with data collected annually between 2011 and 2017, assessed the prevalence and effect of symptoms that commonly co-occur among community-dwelling older adults in the US. At baseline, they assessed pain, fatigue, breathing difficulty, sleeping difficulty, depressed mood, and anxiety among a total of 7,609 community-dwelling Medicare beneficiaries, 65 years or older. Prevalence of zero, one, two, three, and four or more symptoms was 25.0%, 26.6%, 20.7%, 14.0%, and 13.6%, respectively. Symptom count increased as patients got older; compared to men, women had a higher symptom count. The most common co-occurring symptoms were pain and fatigue. Decreased physical capacity was noted in correlation with higher symptom count. For improving outcomes, these symptoms could be potential treatment targets and should be always be recorded in health records.