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Clinical and pathologic findings of aortic dissection at autopsy: Review of 336 cases over nearly 6 decades

American Heart Journal Jan 21, 2019

Huynh N, et al. – In this study, researchers assessed the clinical and pathological findings of aortic dissection (AD) over a period of nearly 60 years. Using the Jesse E. Edwards Registry of Cardiovascular Disease database, they searched for cardiac specimens from autopsies with AD as a diagnosis and compared two cohorts: early (1956-1992) and current (1993-2015). A total of 338 cases with AD were included across both cohorts. They found at 62% of cases were under medical care at time of death (61% in early and 62% in the current cohort), and observed similar risks for dissection between the two cohorts. They identified a correlation between AD death and rupture of the aorta in most cases. Overall, >6 0% of AD cases were first recognized at autopsy rather than clinically. The most common risk determinants for dissection remained alike in both the time intervals.

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