Zhou X, et al. - In this cohort study comprised of 1,036 acute myocardial infarction (AMI) patients, researchers used Cox regression analysis to assess the prognostic value of serum vaspin (visceral adipose tissue–derived serpin) for predicting major adverse cardiac events (MACE). Patients with MACE could be significantly differentiated by serum vaspin, as indicated by receiver operating characteristic curve, with 0.62 ng/mL being the optimal cutoff value. Low vaspin could independently predict MACE upon multivariate Cox regression analysis, together with age; previous histories of AMI, heart failure, hypertension, and diabetes mellitus; Killip class; revascularization; C-reactive protein; and N-terminal pro–B-type natriuretic peptide. Vaspin, in combination with traditional risk factors, significantly improved integrated discrimination and net reclassification improvements for MACE. Overall, the investigators concluded that serum vaspin has significance as a prognostic marker of MACE in AMI patients.