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Independent and joint associations of blood lipids and lipoproteins with lung cancer risk in Chinese males: A prospective cohort study

International Journal of Cancer Jan 17, 2019

Lyu Z, et al. - A prospective cohort study was conducted to assess the independent and joint associations of blood lipids and lipoproteins with lung cancer risk in 109,798 Chinese males from 2006 to 2015. They observed baseline data on total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and non-HDL. They recognized a total of 986 lung cancer cases during a 9-year follow-up. They noted both males with low TC and males with high TC with an increased risk of lung cancer. They also found the number of abnormal indicators was linearly correlated with an increased risk of lung cancer when TC, TG, and LDL-C were considered together. These correlations were found statistically significant among never smokers, never drinkers and overweight/obese men. They suggested dyslipidemia, a modifiable risk factor for the prevention of lung cancer.
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