Roseweir AK, et al. - A total of 150 subjects with stage I-III colorectal cancer were assessed to estimate the relationship between monocarboxylate transporter (MCT) 1, MCT 2, lactate dehydrogenase (LDH) 1 and LDH 5, the tumor microenvironment, and their consequences in colorectal cancer cases. They observed an association of nuclear LDH-5 with poor prognosis and leaning towards elevated tumor stroma percentage. They also found nuclear LDH-5 + TSP significantly associated with decreased survival independent of stage, increased tumor budding and decreased stromal T-lymphocytes when combined into a single score. Furthermore, cytoplasmic MCT-2 + TSP were noted significantly linked to reduced survival, decreased necrosis, and increased tumor budding. It indicated the promotion of tumor progression via modulation of tumor metabolism by increased stromal invasion.