Nielsen B, et al. - In this research, investigators assessed the correlation between the proportion of nuclei with high chromatin entropy and prognosis in gynecological cancers. They developed a new texture-based biomarker which described each cancer based on the proportion of high–chromatin entropy nuclei on a discovery set of 175 uterine sarcomas as well as on independent validation sets of 246 early-stage ovarian carcinomas and 791 endometrial carcinomas. They observed an increased ratio of high–chromatin entropy nuclei linked to poor clinical consequence. They prognosticated 5-year overall survival for uterine sarcoma candidates with a hazard ratio (HR) of 2.02, time to recurrence for ovarian cancer patients, and cancer-specific survival for endometrial cancer patients with this biomarker. They also found existing prognostic markers supplemented by chromatin entropy.