Mango VL, et al. - In this population simulation study, researchers conducted a cost-benefit analysis of a simulated breast cancer screening program for women with average risk comparing MRI to mammography. Study participants included five million (M) hypothetical women undergoing breast cancer screening. Data reported that MRI screening is more cost-effective than mammography screening in 24 years with subsequent screening. Costs are ultimately saved over time compared with mammography despite the higher initial cost of a breast MRI screening program for women with average risk. This is a conservative estimate given the cost-benefit of additional/earlier breast cancers detected by breast MRI.