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Prognostic factors in patients with soft palate squamous cell carcinoma

Head & Neck Jan 17, 2019

Schernberg A, et al. - Between 1997 and 2012, 156 subjects (71% drinkers, 91% smokers; 19% had synchronous cancer) with a median age of 58 years were analyzed to determine the prognostic factors in subjects with soft palate squamous cell carcinoma (SCC). The candidates were given front-line treatment as following: chemoradiotherapy in 58 (37%), radiotherapy alone in 60 (39%), surgery in 17 (11%), and induction chemotherapy in 21 patients (14%). Researchers observed 41% and 37% of the 5-year actuarial overall survival (OS) and progression-free survival (PFS), respectively. They noted an association of T3-T4 vs T1-T2 stage, N2-N3 vs N0-N1 stage, and neutrophil count >7 g/L with worse OS and PFS. Conclusively, they found a link of inflammation biomarkers to OS in subjects with soft palate SCC.
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