Medenwald D, et al. - Researchers explored the link between serum fatty acid profiles and coronary heart disease (CHD) risk in the CARdio-vascular Disease, Living and Ageing in Halle study (CARLA study), which is an observational cohort study including an older adult's general population with a high level of cardiovascular risk factors. Compared to 146 controls matched for sex and age, the serum fatty acid concentrations of 73 subjects with an incident fatal or nonfatal CHD event were assessed in a matched case–control design. As far as current dietary recommendations were concerned, the CARLA study participants were underserved in unsaturated fatty acids. Cases vs controls exhibited no remarkably different fatty acid patterns. Overall, serum fatty acid levels were not associated with CHD risk in populations with a homogenous low level of omega-3 polyunsaturated fatty acids consumption.