Zhou HB, et al. - In this review of 535 consecutive patients hospitalized with acute heart failure (AHF), researchers assessed the link between changes in uric acid (UA) levels with renal function change, diuretic doses, and mortality. At admission and either at discharge or on approximately the seventh day of admission, participants had measurements for UA levels. Those with an UA change in the top tertile were defined as having an increase (UA-increase). These subjects were compared to those outside the top tertile (non-UA-increase). Participants were followed-up for a mean duration of 22.2 months, with all-cause mortality being the endpoint. An increase in creatine levels and daily diuretic dose was reported in association with an increase in UA during in-hospital treatment. Only those with hyperuricemia on admission, showed an association of UA-increase with increased mortality. AHF patients may be better stratified with a combination of UA levels at admission and UA changes on serial assessment during hospitalization.