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Association of obstructive sleep apnea with cardiovascular outcomes in patients with acute coronary syndrome

Journal of the American Heart Association Jan 17, 2019

Fan J, et al. - Researchers examined the association of obstructive sleep apnea (OSA) with subsequent cardiovascular events following acute coronary syndrome (ACS) onset with a prospective cohort study and a landmark analysis with 804 consecutive eligible patients admitted for ACS between June 2015 and May 2017 and had cardiorespiratory polygraphy during hospitalization. A total of 403 patients had OSA. The OSA group vs the non-OSA group had significantly higher cumulative incidence of major adverse cardiovascular and cerebrovascular event (MACCE) during median follow-up of 1 year, but no significantly different incidence of cardiovascular death, myocardial infarction, and ischemia-driven revascularization, other than a higher rate of hospitalization for unstable angina. Overall, no independent correlation was found between OSA and 1-year MACCE after ACS; only after 1-year follow-up, OSA was found to be related to an increased risk. After 1 year, patients with OSA had 3.9 times the risk of incurring a MACCE, as seen in the landmark analysis.

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