Blood kidney injury molecule–1 predicts short and longer term kidney outcomes in patients undergoing diagnostic coronary and/or peripheral angiography—Results from the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) study
American Heart Journal Jan 17, 2019
Ibrahim NE, et al. - Researchers studied the role of measuring blood levels of kidney injury molecule-1 (KIM-1) in predicting kidney outcomes in 1,208 prospectively enrolled patients undergoing coronary and/or peripheral angiography for various indications. They identified predictors of non-procedural acute kidney injury (AKI) by using univariate and multivariable Cox proportional hazards models. To assess peri-procedural AKI and predictors of progression to chronic kidney disease (CKD), univariate and multivariable logistic regression analysis was used. Peri-procedural AKI occurred in 5.0%, non-procedural AKI in 27.3%, and 12.4% developed new reduction in estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 during a mean follow up of 4 years. Findings suggested that blood concentrations of KIM-1 can predict incidents of peri-procedural and non-procedural AKI and progression to CKD in a typical at-risk population undergoing coronary and/or peripheral angiography.
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