Reynolds A, et al. - In this series of systematic reviews and meta-analyses on the link between carbohydrate quality and health, researchers quantified the predictive potential of several markers more precisely, identified which markers are most useful, and established a basis for quantitative recommendations for dietary fiber intakes. This investigation involved prospective studies published from the beginning of the database to April 30, 2017, and randomized controlled trials published from the beginning of the database to February 28, 2018, which reported on indicators of carbohydrate quality and non-communicable disease incidence, mortality, and risk factors. Findings from prospective studies and clinical trials correlated with relatively high intakes of dietary fiber and whole grains were complementary, and striking dose-response evidence shows that the connections to several non-communicable diseases could be causal. It is expected that the implementation of recommendations to increase intake of dietary fibers and replace refined grains with whole grains will benefit human health. The ability to examine key indicators of carbohydrate quality in relation to a range of non-communicable disease outcomes from cohort studies and randomized trials in a single study was a major strength of the study. The results of the study are limited to the overall risk reduction in the population rather than those with chronic disease. When daily intake of dietary fiber was between 25 g and 29 g, risk reduction associated with a range of critical outcomes was greatest.