Jacobsen LM, et al. - Researchers used The Environmental Determinants of Diabetes in the Young (TEDDY) study to develop a risk algorithm to predict progression to type 1 diabetes in children with high-risk human leukocyte antigen (HLA) genes. Thirty-eight candidate risk predictors from clinical, immunological, metabolic and genetic data were examined for logistic regression and 4-fold cross-validation. TEDDY participants with at least one persistent autoantibody confirmed at age 3 were assessed, with the primary endpoint being progression to type 1 diabetes by age 6. In total, 363 patients had at least one autoantibody at 3 years of age. They found that 21% of them had type 1 diabetes at 6 years of age. This study highlighted the application of precision medicine techniques in TEDDY subjects to predict progression to diabetes over a 3-year window. This multifaceted model offers preliminary improvements over simpler prediction tools.