Shen Y, et al. - In patients with type 2 diabetes mellitus, researchers studied the association of high-density lipoprotein cholesterol (HDL-C) with total and type-specific stroke risk. Study participants included 27,113 black and 40,431 white individuals with type 2 diabetes mellitus. Via using Cox proportional hazards regression models, the investigators estimated the association of different levels of HDL-C with stroke risk. A total of 8,496 patients developed stroke (8,048 ischemic and 448 hemorrhagic) during a mean follow-up period of 3.0 years. Among patients with type 2 diabetes mellitus, consistent inverse associations were noted between HDL-C and the risk of total, ischemic, and hemorrhagic stroke. They observed that this inverse association was consistent between patients of different ages, races, sexes, body mass index measures, hemoglobin A1c levels, smoking status (past or present), and patients with and without glucose-reducing, cholesterol-reducing, or antihypertensive agents in this retrospective cohort study.