Yeh CF, et al. - Researchers used the PubMed and Embase databases, as well as Google Scholar, to compare the diagnostic accuracy of neutrophil CD64 to that of C-reactive protein (CRP) and procalcitonin (PCT) for infection detection in adult patients with septic syndrome, based on sepsis-2 criteria. This meta-analysis included 14 original studies (n=2,471). The investigators estimated pooled sensitivity, specificity, diagnostic odds ratio (DOR), and hierarchical summary receiver operating characteristic (SROC) curve. In adult patients with septic syndrome, neutrophil CD64 allowed detection of infection with pooled sensitivity and specificity being 0.87 and 0.89, respectively. The area under the SROC curve and the DOR were 0.94 and 53, respectively. A larger area under the SROC curve was reported for neutrophil CD64 vs for CRP (0.89 [95% CI 0.87–0.92] vs 0.84 [95% CI 0.80–0.88], P < 0.05) or PCT (0.89 [95% CI 0.84–0.95] vs 0.84 [95% CI 0.79–0.89], P < 0.05). Overall, neutrophil CD64 levels demonstrated moderate accuracy, with better performance than CRP or PCT, and were acknowledged as an excellent biomarker in adult patients with septic syndrome.