de Neree tot Babberich MPM, et al. - In this population-based comparative cohort study, researchers compared surgical outcomes of patients diagnosed as having colorectal cancer (CRC) through the fecal immunochemical test–based screening program (screen detected) and patients with non–screen-detected CRC. Using the Dutch ColoRectal Audit, they included patients who underwent elective resection for CRC between January 2011 to December 2016. They observed that screen-detected rectal cancer had significantly higher odds on mortality. Compared to non–screen-detected patients, postoperative outcomes were significantly better for patients with colon cancer referred through the fecal immunochemical test-based screening program. In patients with rectal cancer, these differences were not found. After an extensive case-mix correction, the results of patients with screen-detected colon cancer were still better, suggesting additional underlying factors favoring patients referred for surgery through the screening program.