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Respiratory morbidity in young people surviving cancer: Population-based study of hospital admissions, treatment-related risk factors and subsequent mortality

International Journal of Cancer Dec 20, 2018

Smith L, et al. – Researchers evaluated respiratory hospital admissions among long-term survivors of childhood and young adult cancer to identify specific respiratory morbidities, treatment-related risks, and their associations with subsequent morbidity and mortality in this study. For this purpose, they linked and examined admissions data from population-based cancer registrations in Yorkshire, England (cancer diagnosis, years: 1990-2011; patient age range: 0-29 years) and Hospital Episode Statistics up to 2017. All 5-year survivors (n=4,235) were included in the analysis. They compared admission rates to age- and sex- matched general population rates. Upon analysis, they noted a significantly increased risk of respiratory complications among survivors of childhood and young adult cancer, even several decades after treatment. For all respiratory conditions and pneumonia, an increased risk of admission was noted among those who received treatment with chemotherapy with known lung toxicity. The highest subsequent mortality was observed in those admitted for pneumonia vs other respiratory conditions. The investigators stressed the importance of clinical initiatives for prevention, early detection, and treatment of respiratory complications in this patient population.

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