Yang R, et al. - Researchers studied 3 discriminative circulating microRNAs (miR-21, miR-23a and miR-145) and a combined microRNAs panel based on the data from microRNA microarray of Caterina Musolino's study on 140 female Sprague-Dawley rats (10-12 months old, 240-280 g) to introduce a novel strategy for diagnosing bisphosphonate-related osteonecrosis of the jaw (BRONJ) and alert its induction. They found 3 circulating microRNAs differing between control and BRONJ with an area under the curve (AUC) value < 0.80. They observed a combined index of the 3 microRNAs which profoundly improved the diagnostic performance of BRONJ with an AUC of 0.82, specificity of 63.33%, and accuracy of 71.67% as compared to particular microRNAs.