Diaz KM, et al. – Experts used isotemporal substitution techniques to assess if replacing total sedentary time with light- or moderate-intensity physical activity and replacing prolonged sedentary bouts with shorter sedentary bouts is related to any reduction in all-cause mortality risk. For this purpose, they evaluated study participants (n=7,999) from the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study, a cohort of US adults aged ≥ 45 years. They measured sedentary time using accelerometry (2009-2013). According to findings, short sedentary bouts are still associated with mortality risk and are not a healthful alternative to prolonged sedentary bouts. The investigators indicated that physical activity of any intensity is necessary to mitigate mortality risks incurred by sedentary time.