Bae SC, et al. - Authors evaluated whether alcohol intake is causally related to systemic lupus erythematosus (SLE) in this study. They performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. A causal inverse association between alcohol intake and SLE occurrence was not supported by the results of Mendelian randomization (MR) analysis. They noted consistent MR estimates, which were determined using the IVW, weighted median, and MR-Egger regression methods. No sole single nucleotide polymorphism drove the IVW point estimate, according to results from a “leave-one-out” analysis.