Anderson C, et al. - In the National Institute of Environmental Health Sciences Sister Study cohort, researchers compared 10-year cardiovascular disease (CVD) risk trajectories and major risk factors (changes in weight, body mass index, waist circumference, and systolic blood pressure) between 813 women with and 1,049 women without an incident breast cancer diagnosis. All analyses were stratified by menopausal status at the time of enrollment. Moderate increases in weight, waist circumference, systolic blood pressure, and CVD risk were observed in women who were premenopausal at the time of enrollment, while little change in weight but increases in waist circumference, systolic blood pressure, and CVD risk were observed in those who were postmenopausal at the time of enrollment. In women who developed incident breast cancer vs those who did not, similar results were noted over time with respect to changes in CVD risk, adiposity measures, and blood pressure. Neither chemotherapy nor endocrine therapy were found to be related to greater increases in CVD risk or risk factors.