Grahl JJ, et al. – Researchers investigated the possible varying effects of different classes of antimicrobials on the daily risk of delirium after adjusting for critical illness. For this purpose, they conducted a nested cohort study that included non-neurological critically ill adults from a medical or surgical intensive care unit (ICU) with a daily follow-up to 30 days. They analyzed 418 ICU patients; delirium occurred in 308 (74%), with a median of 3 days among those affected, and 318 (76%) were exposed to antimicrobials. The odds of delirium doubled in correlation with the reception of first-, second-, and third-generation cephalosporins after baseline comorbidities, ICU type, the course of critical care, and other competing antimicrobial and psychotropic medication risks were adjusted for. No association was noted between delirium and cefepime, penicillins, carbapenems, fluoroquinolones, or macrolides.