Fu Y, et al. - In order to investigate the association of psoriasis with inflammatory bowel disease (IBD), researchers carried out a systematic review and meta-analysis. Findings suggested a significant association of psoriasis with IBD. When patients with psoriasis present with bowel symptoms, a gastroenterology consultation is suggested.

Methods

• MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched for relevant studies from the start to January 17, 2018 for this investigation.
• Researchers included the case-control, cross-sectional, or cohort studies that examined either the odds or risk of IBD in patients with psoriasis.
• In the search, no geographic or language limitations were used.
• The PRISMA and MOOSE guidelines for data extraction were followed.
• In order to assess the risk of bias of included studies, the Newcastle-Ottawa Scale was used.
• They separately analyzed Crohn disease and ulcerative colitis and conducted random-effects model meta-analysis.
• They performed a subgroup analysis on psoriatic arthritis.
• Main outcomes and measures included the risk and odds of IBD, Crohn disease, and ulcerative colitis in patients with psoriasis.

Results

• There were a total of 5 case-control or cross-sectional studies and 4 cohort studies with 7,794,087 study participants.
• Psoriasis and Crohn disease (odds ratio, 1.70; 95% CI, 1.20-2.40) and psoriasis and ulcerative colitis (odds ratio, 1.75; 95% CI, 1.49-2.05) were significantly associated.
• The risk of Crohn disease (risk ratio, 2.53; 95% CI, 1.65-3.89) and ulcerative colitis (risk ratio, 1.71; 95% CI, 1.55-1.89) was increased in patients with psoriasis.